Peter Navarro is Right. Give Them Hydroxychloroquine

Discussion in 'Coronavirus Pandemic Discussions' started by stratego, Apr 6, 2020.

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  1. Labouroflove

    Labouroflove Well-Known Member Past Donor

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    Let's stop with the fear mongering.

    https://mobile.twitter.com/aknappjr/status/1247497984431943680

    Immediate Treatment for Early Stage SARS-CoV-2 Infections recommended. M.D.'s please share. There is a link at the bottom to sign if you agree.

    https://docs.google.com/document/d/...SFhO6_8vJK19BUispAREVcn0oi09iajG-Pq4HDCMFTQdg
    Immediate Treatment for Early Stage SARS-CoV-2 Infections Recommended To Be Supported Nationally Starting Now

    A strategic principle and practical approach to rapid response to novel pandemics

    Written by Dr Ben Kaplan Singer, MD; Dr Daniel Stickler, MD; Dr Avery J. Knapp Jr., MD; with many contributing doctors.


    BOTTOM LINE: Our primary strategic objective must be to prevent ICU overwhelm, which on our current course is imminent in most states. It is an axiom of infectious diseases that treatment in earlier stages is more effective than treating advanced stages. Early COVID-19 treatment is more likely to prevent disease progression to critical status, radically lowering hospitalizations and CFR than inaction. Current clinical drug trials are mostly focused on treating late stages of disease, when immunologic damage is a dominant threat. We believe that trials should focus on earlier stage infection to prevent progression to advanced disease. Given the suggestion of efficacy of hydroxychloroquine (HCQ), and the imperative to treat disease before it progresses to cytokine storm, we believe that the current data are sufficient to recommend FDA provisional approval for early outpatient treatment of COVID-19 with HCQ plus zinc and azithromycin. This triple combination treatment can be modified where needed in patients with prolonged QTc or other contraindications at the physicians’ discretion Following this same rationale, we recommend that other clinical trials involving drugs that have already been approved for non-COVID-19 diseases, and for which the safety profile is well understood and reasonably acceptable, should begin clinical trials on patients in early stages of COVID-19 disease, alongside patients with more advanced disease.


    OVERVIEW: ICU overload in the U.S. is impending in the very near term unless immediate actions are taken that effectively reduce hospitalization needs. In addition to the critical efforts underway to decrease Ro and increase ICU capacity, advancing early outpatient treatment with known medications may be the fastest and simplest way to decrease hospitalizations and mortality rate. Given that case fatality rate and harm to frontline healthcare workers increases dramatically when hospitals and ICUs reach capacity overload, it is imperative that all reasonable approaches to prevent that risk are employed quickly and at scale. The FDA recently gave emergency authorization for hydroxychloroquine for inpatient treatment of COVID-19. Around the same time France’s government authorized broader approval of HCQ for inpatient and outpatient use in infected patients after initial worldwide clinical data suggested potential benefit, especially in earlier stages of infection. We propose the US emergency authorization be extended immediately to include early stage and outpatient treatment at the discretion of the prescribing physician, and that this extension also include the registration of those treated individuals into the “loose research protocol” previously proposed.


    It’s important to note that HCQ, zinc, and azithromycin are very well understood drugs with clear safety profiles; they are widely available, generic, inexpensive, and can be scaled rapidly, including to the developing world, which would be expedited by US leadership in recommendations. Some health authorities have given the typical caution against early treatment until large, peer-reviewed, randomized controlled trials (RCTs) provide conclusive data. We fully support the continued effort to investigate existing and novel pharmaceuticals to determine the best intervention through blinded and controlled trials. Weighing the urgency of this unprecedented situation combined with the effects of inaction plus the relative safety of the drugs and the preponderance of data showing effective early treatment significantly decreases the percentage of cases that progress to needing hospitalization we believe that the proposed recommendation is not only adequately founded but ethically obligate. This suggestion conforms with the widespread precedent to treat infections early to prevent progression and hospitalization even where empirical evidence for treatment would be considered insufficient in formal terms.


    According to ClinicalTrials.gov there are 22 HCQ & COVID-19 trials, with only 1 complete and results not yet published. There is one small RCT from China available in pre-publication. The assessment in this document considers the preponderance of relevant data, factoring information we gathered from doctors currently conducting informal open label studies in addition to the previous clinical trials of these drugs for treating SARS and Coronaviruses and the mechanistic studies. While additional data from the trials in progress will of course be valuable, and will hopefully give additional actionable insights, the data currently available is sufficient for emergency provisional approval.


    TREATMENT:

    • HCQ: 15mg/kg PO in divided loading dose followed by 400-800mg/day in divided doses for 4-9 days

      • Obtain baseline EKG for QTc, check on day 3 (or remote monitoring of QTc)

      • Check BMP for hypokalemia, Mg, LFTs
    • Zinc: use zinc acetate or gluconate lozenges with minimal excipients and flavorings to provide 18-25mg of ionized zinc taken every 4 hours during days on HCQ

    • Azithromycin: 500mg PO on day 1 followed by 250mg for 4 more days
     
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  2. Natty Bumpo

    Natty Bumpo Well-Known Member

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    "Let's stop with the fear mongering"?

    That was Trump's initial approach on February 25: It's "under control!" It's going to "go way!" "Everybody's getting better!"

    Given what has transpired since then (376,754 confirmed cases in the U.S, 11,752 deaths, last I checked) it appears that it would have been far wiser to heed the "fear mongering" medical experts whose far more competent assessment forcefully contradicted Trump's:

    “It’s not a question of if this will happen but when this will happen
    and how many people in this country will have severe illnesses.

    Disruption to everyday life might be severe.”
    Director of the Centers for Disease Control and Prevention’s National Center for Immunization and Respiratory Diseases

    February 25, 2020

     
    Last edited: Apr 7, 2020
  3. Natty Bumpo

    Natty Bumpo Well-Known Member

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    The bullshit Trump is currently spewing contrasts starkly with the bullshit he was once spewing.

    His crackpot notions concerning vaccinations is an index of his medical acumen that informs upon his currently hyping his preferred snake oil.
    Fake Don likes to play a doctor on tv, but he is actually playing a reality-tv entertainer in the White House.


    [​IMG]
    THE TRUMP WHISPERER
    "I just invested a bootle in 'Novartis.'
    Novartis makes this stuff called 'Hydrocholazine'."
     
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  4. WillReadmore

    WillReadmore Well-Known Member

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    Washington wasn't referring to trade. Our founders stated many times that trade was a separate issue - that we needed trade with England to continue.

    My comment about Iran wasn't about why. It was about how.
     
  5. WillReadmore

    WillReadmore Well-Known Member

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    That's not a reasonable question - nobody should respect the ideas of someone on this board based on their claim to being an expert.

    I refer to medical experts, such as the CDC, the FDA, and individual recognized experts such as Trump's Dr. Fauci.
     
  6. WillReadmore

    WillReadmore Well-Known Member

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    Trump has NO business promoting a drug cocktail for which NO trial results are available for medical scientists to evaluate.

    I'd point out that there are a number of drugs that are in trial today. I certainly hope one or more of them works.

    But, having TRUMP pick a winner based on NO scientific information is just plain wrong.

    And, it is especially wrong when it is causing pain and even death to those who need the drug - which Trump comments have made to be substantially unavailable, since the federal government offers NO help in creating or marshalling scarece supplies.
     
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  7. HereWeGoAgain

    HereWeGoAgain Banned

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    This all goes to show how fantastically irrational the right wing has become. Science works. The proof is all around us. Leave this to the experts. Everyone wants a cure.

    All drugs have side effects. And trump should be put in jail for practicing medicine without a license.
     
  8. WillReadmore

    WillReadmore Well-Known Member

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    This drug has lethal side affects. People who use it are evaluated and watched, as it can cause heart attacks, for example.

    And, your suggestions concerning efficacy are just plain silly. They don't even hold up to the anectdotal claims, let alone science.
     
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  9. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    I didn't realize Trump was prescribing medications. Do you have a link?
     
  10. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    Maybe you should email the FDA and let them know these things. They obviously don't agree with you and your area clearly the expert here.
     
  11. WillReadmore

    WillReadmore Well-Known Member

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    He has promoted its use in at least 2 briefings.
     
  12. WillReadmore

    WillReadmore Well-Known Member

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    They know. The point is that doctors must evaluate whether a patient may safely take the drug.
     
  13. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    Promoting or passing on info he was made aware of? Look past your hate of Trump and look for the positives of a possible life saving drug. Just pretend it was Obama telling your about it and I'm sure your outlook will change quickly.
     
  14. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    Yes and doctors are doing that, or do you need to send email to the doctors as well to make sure they know this?
     
  15. HereWeGoAgain

    HereWeGoAgain Banned

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    How do you claim to know this? Firstly, it is wrong. Secondly, why would you think you have a clue?
     
  16. WillReadmore

    WillReadmore Well-Known Member

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    Doctors treatiing COVID patients do NOT need Trump promoting a drug. They already have actual medical knowledge and a strong network that is fully informed.

    ==>> Stating that there is an effective treatment (when there are only anecdotes) does no more than undermine the need for changes in our individual behavior to protect ourselves.

    Undermining our response is something that Trump has done REPEATEDLY. Masks, but I won't wear one. Separation, but I won't separate. Testing but I won't, Tests exist, but they STILL don't in any effective number. Everything is ok, don't worry. The virus will die from the heat of summer. I don't have to heltp states - they are on their own. I signed the Defense Production act, but I'm not goin gto use it until there is a real emergency (which there already was, and lead time is required). I'm shipping material to NY,, but he only ships it to commercial outlets that receive bids from all states and even globally. etc., etc., etc.

    And NO. Obama isn't a medical expert, either. And, there is no way he would have started promoting drug treatments. And, we know that, because he didn't when he could have.
     
    Last edited: Apr 7, 2020
  17. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    He is not promoting a drug, he is telling about it's findings which is info that is passed to him from doctors and scientists.. You are downright pissed off at being informed. Chill out dude, it's information. No one said you have to take it.
     
    Last edited: Apr 7, 2020
  18. WillReadmore

    WillReadmore Well-Known Member

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    There are no "findings". There are anecdotes. Findings implies there is science being used.

    And again, this just plays into Trump's "strategy" of downplaing the importance of fighting COVID.

    And, that "strategy" leads to more death.

    Trump should be giving clear messages concerning what we need to be doing.

    But, he is not.
     
  19. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    You are just hell bent on this medication not being used. Are you a doctor? Are you a pharmacist or scientist? Then who are you to argue with their findings and the FDA. I'm done with this conversation. If you would rather die if it was your in the hospital, that's your choice.
     
  20. WillReadmore

    WillReadmore Well-Known Member

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    False.

    This disaster is not over. We need a president who is leading an effort to fight the disease.

    False claims and distractions from that are just plain not acceptable.
     
  21. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    False? So you're saying that poster is in fact a doctor, scientist, or pharmacist?
     
  22. WillReadmore

    WillReadmore Well-Known Member

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    I haven't said anyone is a doctor, scientist or pharmacist.
     
  23. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    Then nothing I stated was false.
     
  24. Natty Bumpo

    Natty Bumpo Well-Known Member

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    Ignore what Trump tells you. He's a notorious bs artist, not a pharmacologist despite his delusional pretense.

    Here is a real development about which there is reason for guarded optimism:

     
    Last edited: Apr 7, 2020
  25. Louisiana75

    Louisiana75 Well-Known Member Past Donor

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    Thanks for the link, can’t wait to hear more about this.
     

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