The state of the vaccines

Discussion in 'Coronavirus Pandemic Discussions' started by CenterField, Aug 14, 2020.

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  1. CenterField

    CenterField Well-Known Member Past Donor

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    No. There is a junk science article pushing the version that the Covid vaccines causes dementia. It's been debunked and rated as false. There is no evidence that this is the case.

    https://www.wusa9.com/article/news/...imers/65-5338c59e-4d75-4691-8c3c-0fa86cbe3413

    One, your father might be self-compensating for an insidious process and now he tipped over the edge. Or he may be suffering from one of the faster cases of dementia, such as a sudden worsening of vascular dementia due to a silent mini-stroke that may have affected a memory center, or a prion disease.

    Obviously he needs to be seen by a neurologist and the cause of this rapidly progressive dementia needs to be worked out.
     
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  2. Hoosier8

    Hoosier8 Well-Known Member Past Donor

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    Eric Clapton, Ben Stein, my best friend and many others have all had bad reactions after getting the inoculations, None of them will be investigated why unless they die and even then you have to admit not enough is known to verify that the problems were caused by the inoculations.
     
  3. truth and justice

    truth and justice Well-Known Member

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    Unfortunately I am not able to open your link in my country.

    Thank you very much for your reply. I don't think that he was self-compensating as there was a distinct change in memory problems from good memory to bad memory over a few weeks. A mini stroke is possible as he was always on the go regarding business matters. Trouble with this is that it appear that nothing can be done to help him as he has always carried out the recommendations for reducing chance of strokes - doesn't drink, doesn't smoke, not overweight, normal BP and average cholesterol levels. And if it is a prion disease there is nothing that can help him. So I need to think, do I need to put him through the stress of examinations if nothing can be done to help anyway.

    Are there any other conditions that can exhibit these symptoms, such as infections, which can be treated?

    Sorry for going off topic. I initially inquired about the vaccine side effects because he is soon due the booster
     
  4. 557

    557 Well-Known Member

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    My mom had dementia. Every time she had general anesthetic for another condition (gall bladder, et.) her cognitive function and memory would take a huge immediate hit.

    Good question about vaccines exacerbating the condition. It’s not advertised but in rare cases vaccines can induce sequelae similar to that from the disease it’s designed to prevent. If an individual is predisposed to injury from an immune response it may not matter if the immune response is natural or vaccine induced. That said it’s highly unlikely. But unlikely is meaningless when it’s someone you love. My father in law just got out of the hospital—almost died of Covid. Fully vaccinated. Unlikely, but not impossible.

    Sorry about your dad. Don’t miss any opportunities to say or do things today with your dad that will bring you both joy.
     
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  5. CenterField

    CenterField Well-Known Member Past Donor

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    You might try to get a VPN (you can find some free and reliable ones online, like Proton VPN), simulate your online presence in my country, and then open the link.

    Oh yes, there are reversible causes of dementia that need to be worked out; metabolic, infectious... No, don't get a fatalistic approach to it, thinking nothing will help anyway. While the majority of dementias at his age are irreversible and progressive, some are not; what if his is a reversible one and nothing gets done from not getting him to see a specialist? Also, some of the irreversible ones can at least be slowed down with treatment. He needs neuroimaging, EEG and lab tests to look at metabolic and infectious causes. Also, if neuroimaging diagnoses a mini-stroke he will need prophylactic treatment to avoid a repeat. He absolutely must be seen.
     
    Last edited: Sep 16, 2021
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  6. CenterField

    CenterField Well-Known Member Past Donor

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    I do find it highly unlikely. At age 82, to start with, he is not likely to have had a huge immune response to the vaccine anyway. We see for example myocarditis from the vaccine-induced spike proteins in much younger people. While the whole virus itself can cause cognitive deficits, I find it extremely unlikely that this is coming from the vaccine. I believe that the timeline is just a coincidence. We've seen these issues over and over - a very old person gets a vaccine, then presents with some other condition that would have happened anyway due to the person's age (worsening dementia at age 82 is not exactly a rare occurrence) and people attribute it to the vaccine. I know you aren't one of those who are prone to this kind of jump to conclusions as you are a thoughtful and science-minded individual, but it's worth posting here because you're not the only one reading this thread.

    Let's put it this way: there are tones of possible causes for Truth and Justice's father's worsening dementia. They need to be worked out. If everything is ruled out than maybe, big maybe, we might consider more closely the unlikely possibility that the vaccine had something to do with it.

    @truth and justice

    At this point what is indicated is a full dementia work-up to diagnose the kind of dementia, see if it is one of the rarer causes (at his age) that are reversible, treat if reversible, and if not reversible but possible to slow its progression down, treat it, and if no response to any of that, implement the auxiliary measures that help a demented person like sleep hygiene, sunlight, environmental cues, steady and familiar routine, family support, reassurance and assistance with reminders for tasks and ADLs, etc., etc.

    One shouldn't sit on a case of worsening dementia at age 82. Proper diagnosis and management are imperative. Of course we know that many (or even most) of these cases are bleak and little can be done, but some aren't. You need to give him the opportunity to recover or to slow down the process for the treatable kinds, and again, if this is vascular and mini-stroke related he may need preventative anticoagulation.
     
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  7. 557

    557 Well-Known Member

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    @CenterField , @truth and justice

    We are on the same page as far as the likelihood of this event being “caused” by vaccination. I think we just have enough information to say we couldn’t rule vaccination out as a contributing factor. That’s why I referred generically to predisposition.

    Just one example of a possible scenario. We know cortisol levels predict dementia and can trigger dementia in those predisposed. We know stress and immune response to viral antigen increases cortisol levels. T&J’s father is 82 and working every day. Probably high cortisol from baseline stress. A cortisol dump from cytokine activity after vaccination pushes him to symptomatic dementia.

    Both autoimmune disease and infection are recognized as triggers for RPD
    https://memory.ucsf.edu/dementia/rapidly-progressive-dementias

    Again, I’m not diagnosing this man. Just pointing out the mechanisms exist and are understood well enough we can’t rule out a vaccination event having involvement in dementia onset.
     
    Last edited: Sep 16, 2021
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  8. CenterField

    CenterField Well-Known Member Past Donor

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    Maybe we can't entirely rule it out but we agree that it's highly unlikely. I believe that if (hopefully, when) a full work-up is done, a different cause will be found.
     
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  9. CenterField

    CenterField Well-Known Member Past Donor

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    Very important paper regarding boosters, generally against them for now. Two of the authors are the FDA officials who are stepping down, unhappy with how the White House managed the issue of boosters.

    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02046-8/fulltext

    As you all probably know, the FDA today voted against providing boosters for all people 16 and over, by a vote of 16-3. However it also voted unanimously for providing boosters to people 65 and older, and to people at risk for severe disease. They did not define that latter category, deferring to the CDC in the definition of who qualifies as at risk for severe disease. The CDC will meet twice this coming week, to come up with a recommendation. The CDC currently already has a definition of high risk, so it should be very similar.

    This lay press article has also some good information about de declining efficacy of the immunity provided by the Pfizer and the Moderna vaccines:

    https://www.yahoo.com/news/pfizer-moderna-revealed-way-theyre-210137529.html
     
  10. CenterField

    CenterField Well-Known Member Past Donor

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    In addition to the previously approved immunocompromised, Pfizer boosters will now go to the following categories, after today's CDC decision:

    Six or more months after the second dose, boosters were authorized for anyone 65 years and older; residents of long-term care facilities; any 50-64 year-olds with underlying medical conditions; and 18-49 year-olds with underlying medical conditions based on individual risk-benefits balance.

    Surprising, the CDC denied boosters to people who are not in one of the above categories but are exposed in virtue of their jobs, such as healthcare workers, grocery store workers, teachers, and first responders.

    I consider it a grave mistake. In doing so, the CDC considered that these people are not at risk of severe disease because they are vaccinated and healthy. Well, what the CDC failed to consider is that if a booster multiplies by a factor of ten the titers of neutralizing antibodies, these workers would be much less likely to catch and transmit the disease to people they interact with in their jobs, such as vulnerable patients, grocery store customers, students, etc.

    So, the decision contributes to the spread of the disease. I would have included these categories.
     
    Last edited: Sep 24, 2021
  11. CenterField

    CenterField Well-Known Member Past Donor

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    In a move I approve of, the CDC director did re-establish the booster for those in high-risk professions such as healthcare workers, etc., in line with the FDA. Good.
     
  12. Montegriffo

    Montegriffo Well-Known Member

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    Everyone over fifty is being offered the booster here, 6 months after their second jab
     
  13. CenterField

    CenterField Well-Known Member Past Donor

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    Good. I'm for these boosters. I think there is enough evidence by now that they greatly enhance the neutralizing antibodies titer, and are safe.
    Given that my category is within the CDC recommendation, I should be eligible for my booster, soon, and will accept it with no hesitation whatsoever.
     
  14. CenterField

    CenterField Well-Known Member Past Donor

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    Two very important studies, one published on Lancet, the other one still pre-print, show that the Pfizer vaccine, while dramatically dropping in effectiveness against infection, does continue to have high efficacy against hospitalizations, regardless of the variant.

    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02183-8/fulltext

    https://www.biorxiv.org/content/10.1101/2021.09.30.462488v1.full.pdf

    So here's the bad: both neutralizing antibodies and T-cell-mediated immunity drop dramatically after six months.

    Here's the good: it's not because of the Delta variant so there is no need to adapt boosters to Delta; just giving a booster with the same vaccine should fix the problem.
     
  15. CenterField

    CenterField Well-Known Member Past Donor

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  16. CenterField

    CenterField Well-Known Member Past Donor

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    Sweden, Finland and Denmark don't want to give the stronger Moderna shots to males younger than 30 due to a slightly bigger risk of myocarditis. They are recommending the Pfizer one for this age group.
     
  17. kreo

    kreo Well-Known Member

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    It looks like more and more side effect is coming, but government insist on indiscriminate continuous vaccinations.
     
    Last edited: Oct 13, 2021
  18. CenterField

    CenterField Well-Known Member Past Donor

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    A new (but rare) side effect to the mRNA vaccines has been reported.

    Parsonage-Turner syndrome. It came up in a recent pharmacovigilance monitoring report from the French National Agency for the Safety of Medicines and Health Products (ANSM).

    The rare condition is characterized by the sudden onset of severe pain in the shoulder, followed by arm paralysis. The cause is not fully understood. We've seen a few cases with the flu shot. Six cases were reported with the Pfizer, and three with the Moderna. Do realize that this is out of hundreds of millions of doses given.
     
  19. truth and justice

    truth and justice Well-Known Member

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    Following on from another thread:

    Just a question. If I remember correctly I read somewhere that the cell that the mRNA enters manufactures the spike proteins and then dies releasing these spike proteins. Is this correct?
     
  20. CenterField

    CenterField Well-Known Member Past Donor

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    Not immediately. The cell presents the spike protein in its surface. The process of making the spike proteins doesn't immediately kill the cell, unlike wild whole viral replication. But what can happen is that activated killer T cells will look at the spike protein and "think" not-self and will kill the cell. This is helpful because once the cell dies, more spike protein fragments are released, fostering more immune response.

    Here's an infographic:

    https://www.dsh.ca.gov/COVID-19/docs/Vaccination/COVID-19_Messenger_RNA_Vaccine_Information.pdf
     
  21. CenterField

    CenterField Well-Known Member Past Donor

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  22. CenterField

    CenterField Well-Known Member Past Donor

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    The FDA has recommended boosters for Moderna and J&J and also the mix strategy; a person who had a vaccine brand for basic vaccination will be able to pick a different one for a booster. Excellent move, supported by the limited but existing research showing that mixing yields higher antibodies than repeating the same vaccine for the booster.
     
  23. CenterField

    CenterField Well-Known Member Past Donor

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  24. kreo

    kreo Well-Known Member

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    Yep, it works pretty well against Wuhan and Delta
    but those variants are the history already.
    May be it is a time stop fooling people?
    Looking at statistics it is pretty clear that vaccines are useless against common cold infections.
     
  25. EyesWideOpen

    EyesWideOpen Well-Known Member Past Donor

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    It will not end with just the vax, and then a booster.

    This virus will never simply go away. If these federal vax mandates are not halted, we will be forced to take boosters forever. I don't even think we will be able to question what's in them either. The feds say "take this shot or else," and I doubt they will care what we think, once they can mandate us to take them.
     

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