What part do genetics play in mental illness?

FactChecker · Jun 15, 2012

Jebediah said: ↑

Nope. I will continue to post in this one and debunk bigoted lies.

The posts in this thread are foolish. The sweeping statements about genetics are not backed up by scientific fact.
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Which of my statements about genetics is not backed up by scientific fact?

Jack Napier · Jun 15, 2012

FactChecker said: ↑

Which of my statements about genetics is not backed up by scientific fact?
Click to expand...

FC - it's not worth getting sidetracked.

These kinds of people have no interest in engaging in civil discourse.

He possibly means the 'paper' that I gave you, to comment on, and examine.

He is effectively saying it's not good to ask questions of those better qualified than myself, and if I cite a psychiatrist, the subject can be anything but Jews, and if it is Jews, I must find a scientist that draws only positive, if inaccurate conclusions, about Jews. Then it would be okay.

Citing the work of another man, and asking you to comment on it, is apparently bad.

It would apparently be better just to have remained confused by it, and not ask you.

Odd logic imo.

Jack

waltky · Dec 6, 2017

Existing cancer medication might be used to treat Huntington's disease...

Existing cancer medication offers potential to treat Huntington's disease
December 6, 2017 - A drug already used to treat certain forms of cancer may also be an effective therapy for Huntington's disease, according to a new study in the latest issue of Science Translational Medicine. The same study also increases our understanding of how this drug, and other medications like it, may offer hope for other neurodegenerative diseases like Alzheimer's disease, amyotrophic lateral sclerosis (ALS), and Parkinson's disease.

Huntington's disease is a devastating, inevitably fatal disease, with no medications that slow or stop disease progression. In this study, mice with the equivalent of Huntington's disease became more mobile, recovered from neurodegeneration, and lived longer after being treated with bexarotene. The same research builds on a 2016 study where La Spada and his team showed that the drug KD3010 is an effective treatment for Huntington's disease in mice and in human patient neurons made from stem cells. Senior author Al La Spada, MD, PhD, (photo) said the study results are exciting not just because these drugs worked, but because of how they worked. "It's not just the response from the drugs, but the mechanistic pathways these drugs are targeting," said La Spada, director of the forthcoming Duke Center for Neurodegeneration and Neurotherapeutics. "These pathways are relevant to other neurodegenerative disorders and potentially the aging process, itself in addition to Huntington's disease."

Bexarotene and KD3010 function by activating PPARδ, a transcription factor that keeps neurons functional in two ways: by keeping mitochondria healthy and active, and by helping neurons remove dysfunctional proteins. Mice—and humans—with Huntington's disease have problems activating PPARδ. When La Spada and colleagues treated Huntington's mice with bexarotene or KD3010, they observed improved mitochondrial health in neurons, as well as increased removal of damaging misfolded proteins. The same factors of impaired mitochondrial function and protein misfolding are recognized as increasingly important in diseases like Alzheimer's disease, Parkinson's disease, and ALS.

A montage of three images of single striatal neurons transfected with a disease-associated version of huntingtin, the protein that causes Huntington's disease. Nuclei of untransfected neurons are seen in the background (blue). The neuron in the center (yellow) contains an abnormal intracellular accumulation of huntingtin called an inclusion body (orange).

The study doesn't mean that patients with Huntington's disease or other conditions should rush to get bexarotene or KD3010. Further research needs to determine how to use these drugs in human patients. Bexarotene can have difficult side effects at high dosages, and optimal doses aren't known, while KD3010 has only been tested in human subjects for type II diabetes.

Instead, future therapies for Huntington's disease and other neurodegenerative conditions may take a cue from HIV treatments and involve a "cocktail" approach of combined medications. Lead author Audrey Dickey, PhD, found that, taken together, bexarotene and KD3010 produced better results in cells even when given at lower doses. "With this approach, we could minimize side effects with lower doses of each compound, even when together the treatments provide a higher effect than either one alone," said Dickey. "We are carrying out further research on the underlying mechanisms of neuroprotection and applying this research to other diseases with similar issues of mitochondrial dysfunction and protein quality control, such as Parkinson's disease, Alzheimer's disease, and ALS."

https://medicalxpress.com/news/2017-12-cancer-medication-potential-huntington-disease.html
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What part do genetics play in mental illness?

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