COVID-19 Research, Drug trials and Pathophysiology

Melbourne University has developed a cheap barrier to protect workers from infected patients. I can see a huge role for this especially in third world countries but more importantly it would allow us to deploy one of the most effective and cheap interventions that delay or even prevent the need for intubation and ventilation - high flow nasal prongs

https://about.unimelb.edu.au/newsro...hospital-beds-to-help-contain-covid-19-spread

 

Interesting article, thanks for posting. Made me wonder if there is perhaps an indirect connection where children susceptible to KD are having the symptoms triggered and/or exacerbated by the Covid virus.

FYI there is another study from China about finding the virus in semen. Seems there is no part of the body that cannot be impacted. This raises concerns about it invading a fetus and potential birth defects. Haven't seen any studies in that area yet.

 

Only research only treatments that will gain any support any credibility will be the ones that line the pockets of global elitist
want to know why their was much push back on hydroxychloroquine the all out effort by the global elitist and thier lap dog media to discredit its use and the test done that showed good results
simple reason the drug was already in production been around for decades and its cheap no one was going to make any money from it

want to know what research what treatment will gain support and credibility it will be for drugs which the global elitist has much money invested in

 

Yah!

Sorry mate but I left my tin foil hat at home

Amusing though how a global pandemic affecting multiple countries with thousands of medical staff, biochemists and pathologists in hundreds of different institutions can somehow be part of the “global elite” who are in a conspiracy to show Trump as an idiot pushing nostrums

https://www.nejm.org/doi/full/10.1056/NEJMoa2012410?query=main_nav_lg

It doesn’t work

 

https://nypost.com/2020/05/09/new-york-mom-with-coronavirus-saved-by-medical-student-son/

The hospital diagnosed the mom of four with pneumonia, but with no coronavirus tests available, it sent her home as a suspected COVID-19 case.

Some symptoms improved when Bruzzese, who works in banking, was given the antibiotic azithromycin and the malaria drug hydroxychloroquine — but she still couldn’t breathe.

Horowitz had an idea. He suggested trying glutathione, an anti-oxidant produced by the liver that has been used to reduce inflammation in those suffering from the tick-borne illness.

“When you get a viral infection with a huge amount of inflammation you don’t have enough glutathione to be able to protect your very sensitive lung tissue,” Horowitz said.

James did not hesitate to give his mom the nutritional supplement, which they had in the house for Julia. After one 2,000-milligram dose, the family witnessed a miracle.

“Within an hour my breathing got better. It was amazing. I sat up, I got up,” Josephine Bruzzese recalled. She even started to make her bed. “I went and I took a shower.”

She took the pills for five days and had no relapse, her son said.

 

((((((((((((Sigh))))))))

Did you read ALL of the article?

https://nypost.com/2020/05/09/new-york-mom-with-coronavirus-saved-by-medical-student-son/

Other research (done in silicon only I.e. computer modelling)

https://chemrxiv.org/articles/Novel...ment_Molecular_Docking_and_SAR_Study/12153021

A paper on N-Acetylcysteine a precursor to glutathione in the body

https://www.cebm.net/covid-19/n-ace...dence-for-effectiveness-in-treating-covid-19/

However please note in the original paper

1. There was no conclusive diagnosis of COVID-19
2. This was not a randomised controlled trial
3. We cannot rule out a placebo effect since there was no defined measurable data
4. Highly questionable ethics since it was based on an untested theorem

 

The NYP is one of Rupert Murdoch's click bait tabloids so it is little wonder that it targets it's gullible readership with "miracle cures".

 

((((((((((((Sigh))))))))

Too bad the left don't believe in science.

 

Too bad the right thinks nostrums and wishful thinking = science

 

Assbackwards again!

The left UNDERSTANDS science while it is the right that embraces their Science Denialism beliefs.

 

What gets me is that the brief critique I wrote is medical science 101

 

Which went right over their heads, unfortunately!

 

Two cases with no confirmation they had COVID a doctor they knew and had faith in and two magic pills later and suddenly, miraculously both cases recovered in a short time

Sniff, sniff I smell me a placebo effect

 

Furthermore the magic pills were for inflammation so it would not have had any direct impact on the virus, only the symptoms. Two aspirin could have had the exact same outcome of relieving the symptoms.

 

[Knock on wood for Australia] Fortunately, it looks as though Australia won't be having many opportunities, at least in the near future--and hopefully ever--to try out the protective barrier on Australian COVID-19 patients.

https://www.health.gov.au/resources/daily-number-of-reported-covid-19-cases-in-australia

Congrats on getting your numbers down. Was there ever a better time to be an Aussie?

 

That reminds me of the steam tents they used in paediatrics (in the days when dinosaurs walked the earth).

 

The old “croup tents” that we had to keep filing with ice water because the poor kids inside sweltered?

 

Maaaaaate!

There is never a bad time to be an Aussie

 

It is amazing that people actually believe in this world wide grand conspiracy to make our POTUS look bad. LOL

 

Vitamin D levels appear to play role in COVID-19 mortality rates
Patients with severe deficiency are twice as likely to experience major complications
Date:
May 7, 2020
Source:
Northwestern University
Summary:
Researchers analyzed patient data from 10 countries. The team found a correlation between low vitamin D levels and hyperactive immune systems. Vitamin D strengths innate immunity and prevents overactive immune responses. The finding could explain several mysteries, including why children are unlikely to die from COVID-19.

https://www.sciencedaily.com/releases/2020/05/200507121353.htm

 

Interesting finding about Vitamin D.

Our bodies convert cholesterol into Vitamin D thanks to exposure to sunlight. Australia is well known as a sunny nation which could mean that people there are less likely to have a deficiency whereas in America people tend to spend the majority of their time inside thanks to air conditioning. This is confirmed by this article and the link to the study itself.

https://www.scientificamerican.com/article/vitamin-d-deficiency-united-states/

https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/414878

Both the CDC and the UK have noted a racial disparity in mortality rates in proportion to population demographics.

https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm

https://www.statista.com/chart/21480/england-covid-19-deaths-by-ethnicity/

So it is entirely possible that there is something more to be discovered regarding the virus and Vitamin D. Too early to draw any conclusions.

 

I don't want to get banned, so an honest assessment about how stupid that statement is cannot be given. Suffice to say your understanding of how these things work is primary school level at best.

There are still drug companies charging good money for insulin, a drug which is almost 100 years old and whose discoverers basically gave away the patent to make sure it would be readily available. The idea that because this drug already exists that people can't make money out of it is beyond laughable. If millions upon millions of people need this treatment then EVERYBODY who can make this will make money out of it. LOTS and LOTS of money. Governments all over the world will be falling over themselves to bid for it. So will private healthcare providers. By the time production ramps up to meet the new demand everyone making it will have made a fortune.

Of course, this is commonsense economics informed by stuff that actually happens, so most people here will ignore it.

 

This study was brought to my attention in the tracking thread and while it is not directly about the drug and the pathology it is related research when it comes to the spread and control of the virus and the effectiveness of social distancing measures.

https://www.medrxiv.org/content/10.1101/2020.04.27.20081836v1.full.pdf

The Appendices contain good data WRT to the time frame of the incubation period from infection to symptoms.

Table 3 is very informative as to the drops in R0 in each of the states following Social Distancing protocols. From my own analysis of that table it appears that only the handful of states that managed to bring it under R0.9% are successful at beating the virus.

 

Gilead should ditch remdesivir and focus on its simpler and safer ancestor

https://www.statnews.com/2020/05/14...ivir-and-focus-on-its-simpler-safer-ancestor/

.....snippet....
Data from the open-label SIMPLE trial, sponsored by Gilead, and the randomized controlled Adaptive Covid-19 Treatment Trial, sponsored by the National Institute of Allergy and Infectious Diseases, show that remdesivir may accelerate recovery rates among patients with advanced Covid-19. The drug’s modest effects are a far cry from the strong antiviral activity it demonstrated in preclinical primate models of coronavirus (both MERS and SARS-CoV-2). Yet that has been enough for the Food and Drug Administration to grant emergency use authorization for remdesivir and for the Japanese Ministry of Health, Labour, and Welfare to approve it for the treatment of Covid-19.

As chemists, we are troubled by the challenges to mass producing remdesivir. We aren’t alone. On the day that results from the two trials emerged, Gilead CEO Daniel O’Day praised the chemists behind the drug, saying he is “proud of the team because this is a complicated chemical process. It takes many, many steps.”

But does it really have to be that complicated? O’Day’s admission is interesting given that Gilead has another compound in its pipeline that is easier to make, has been shown to be effective against coronavirus in animal models, and is potentially as effective as remdesivir, if not more so.

 

This is from LIFTL

https://litfl.com/is-covid-19-ards-what-about-lung-compliance/

Although LIFTL is a blog it is highly respected in the medical community as it is one of the cornerstones of FOAMed (Free Open Access Medical Education) a group of Medical specialists dedicated to sharing skills and knowledge world wide